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Long-term prognosis associated with coronary calcification: observations from a registry of 25,253 patients.

27/2/2015

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Budoff et al. set out to investigate the efficacy of Coronary Calcification assessment as an independent risk factor in a large registry of 25,253 asymptomatic patients. They found that Coronary Calcification assessment ‘..was an independent predictor of mortality in a multivariable model controlling for age, gender, ethnicity, and cardiac risk factors’ and ‘the addition of Coronary Calcification assessment, to traditional risk factors, increased the concordance index significantly’ In summary, this large observational study shows that Coronary Calcification assessment is an independent estimator of all-cause mortality.
AUTHOR
Budoff, M.J, Shaw, L.J., Liu, S.T., Weinstein, S.R., Mosler, T.P., Tseng, P.H., Flores, F.R., Callister, T.Q., Raggi, P., Berman, D.S. (2007)
REFERENCE
J. Am. Coll. Cardiol. 49(18):1860-70.
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Absence of coronary artery calcification and all-cause mortality

27/2/2015

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Blaha et al set out to examine the role of Coronary Calcification assessment as a ‘negative’ cardiovascular risk factor in a group of 44,052 asymptomatic patients. They found that in appropriately selected asymptomatic patients, absence of Coronary Calcification predicts excellent survival with 10-year event rates of approximately 1% (<0.1%/year). They also concluded that those patients with very low Coronary Calcification should be considered a ‘distinct albeit low-risk group by physicians and investigators’.
AUTHOR
Blaha,M., Budoff, M.J., Shaw, L.J., Khosa, F., Rumberger, J.A., Berman, D., Callister, T., Raggi, P., Blumenthal, R.S., Nasir, K. (2009)
REFERENCE
J Am Coll Cardiol Img. 2(6):692-700.
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Prognostic value of coronary artery calcium screening in asymptomatic smokers and non-smokers

27/2/2015

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Shaw et al set out to investigate the extent of Coronary Artery Calcium, and if it was of any prognostic significance, in a group of 10,377 asymptomatic individuals [40% of which were current smokers]. Shaw et al. found that ‘Young smokers with high-risk calcium scores have a 4 to 9-fold increased risk of dying when compared with similarly aged non-smokers.’
AUTHOR
Shaw, L., Raggi, P., Callister, T., Berman, D.
REFERENCE
Eur. Heart J. (April 2006) 27 (8): 968-975.
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Coronary calcium score improves classification of coronary heart disease risk in the elderly: the rotterdam study

27/2/2015

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The focus of this study was to examine the role of Coronary Calcification assessment to estimate 10-year Coronary Heart Disease risk in 2,028 asymptomatic elderly patients [mean age of 69.5 years]. Elias-Smale et al. concluded that in a general population of elderly patients at intermediate Coronary Heart Disease risk, Coronary Calcification assessment ‘is a powerful method to reclassify persons into more appropriate risk categories’.
AUTHOR
Suzette E. Elias-Smale, Rozemarijn Vliegenthart Proença, Michael T. Koller, Maryam Kavousi, Frank J.A. van Rooij, Myriam G. Hunink, Ewout W. Steyerberg, Albert Hofman, Matthijs Oudkerk, Jacqueline C.M. Witteman (2010)
REFERENCE
J Am Coll Cardiol. 2010;56(17):1407-1414.
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Expert review on coronary calcium

27/2/2015

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This article provides an in-depth review pertaining to the clinical use of Coronary Calcification for assessing coronary atherosclerosis as a useful predictor of coronary artery disease in certain population of patients.
AUTHOR
Budoff, M.J, Gul, K. (2008)
REFERENCE
Vasc Health Risk Manag. 2008 April; 4(2): 315–324.
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Age and gender distributions of coronary artery calcium detected by electron beam tomography in 35,246 adults.

27/2/2015

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This study set out to develop a set of age- and gender-stratified Coronary Calcification score distributions which would subsequently aid clinicians to interpret Coronary Calcification scores from EBT scans. 35,246 asymptomatic subjects, 30 to 90 years of age, were self-referred for Coronary Calcification screening using an Imatron EBT scanner. In summary, this study reports differences in total Coronary Calcification scores that exist between men and women of various ages.
AUTHOR
Hoff, J.A., Chomka, E.V., Krainik, A.J., Daviglus, M., Rich, S., Kondos, G.T. (2001)
REFERENCE
Am. J. Cardiol. 2001 Jun 15; 87(12): 1335-9.
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Identification of patients at increased risk of first unheralded acute myocardial infarction by electron-beam computed tomography.

27/2/2015

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This study examined a cohort of 632 asymptomatic patients, referred for EBCT screening by primary care physicians because of the presence of risk factors for CAD. They found that the incidence of cardiovascular events was greatly increased in the presence of Coronary Calcification and the majority of events occur in patients with mild to moderate amounts of Coronary Calcification. Conversely, high age- and sex-adjusted Coronary Calcification Score percentiles appear to be closely related to the occurrence of subsequent hard events, and they suggest that this measurement should be used in the assessment of the risk of a hard event in asymptomatic individuals.
AUTHOR
Raggi, P., Callister, T.Q., Cooil, B., He, Z-X., Lippolis, N.J., Russo, D.J., Zelinger, A., Mahmarian, J.J. (2000)
REFERENCE
Circulation. 2000; 101: 850-855.
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About the IHDA

The Irish Heart Disease Awareness charity has been established to raise awareness of heart disease as a progressive, measurable and treatable disease that can be detected by a simple calcification test.The charity's founder, David Bobbett, is the CEO and majority shareholder of H&K International, one of the world's largest equipment suppliers to the Quick Service Restaurant (QSR) industry. 

Irish Heart Disease Awareness

Contact Information
Irish Heart Disease Awareness, a Company Limited by Guarantee

Directors
David Bobbett;
Dr. Jerry Clifford
Eric Wallace
Pat Caslin
Caroline O'Sullivan
​
Registered Number – 518296
Registered as a Charity under reference:
CHY 20387
Tel: 01 605 5421


Registered Address:
Knockmitten House,
Knockmitten Lane,
Dublin 12

Email: info@ihda.ie

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